In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. This product is not recommended for use during pregnancy. The terms milk thistle and silymarin are often used interchangeably. Cochrane Database Syst Rev. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. Olive Oil Vs. National Center for Complementary and Integrative Health. It seems to help lower blood sugar. Include all brand names and combination drug names. Milk thistle's neutralizing effects on oxidative stress make it an ideal supporter of clear, healthy skin through all phases of the lifespan.*. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. Silymarin as supportive treatment in liver diseases: a narrative review. One of milk thistle's traditional uses is easing indigestion. Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Check with your physician if you have any of the. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. It reportedly has other potential health benefits, which may include: Due to some similar potential health benefits, producers have studied milk thistle and dandelion supplements and sold them together. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . Consult your healthcare provider if this applies to you. Cathy Wong is a nutritionist and wellness expert. Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. Phytother Res. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Click here for additional information. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. Substances in milk thistle may reduce blood sugar. Rev Diabet Stud. Duplication is encouraged. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. But it may be a helpful complementary treatment to try if a healthcare professional approves it. We encourage you to discuss any decisions about treatment or care with your health care provider. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. ), SAGE Journals. He has been in the digital media field for over eight years. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. Vegetable Oil: Nutrition Fac Olive Oil Vs. Read our. Continue reading. nausea, loss of appetite. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. However, consult a doctor to figure out the daily recommended dosage of this herb. Learn, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). It could also have similar effects on the body to estrogen. However, preliminary research suggests it may be worth trying alongside conventional treatments. How long does it take for milk thistle to start working? Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. What Are the Side Effects of Milk Thistle? Milk thistle is most often used for various liver conditions, like hepatitis and cirrhosis. Some people may be allergic to milk thistle. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. If you notice other effects not listed above, contact your doctor or pharmacist. Current studies on milk thistle use a wide range of doses. These include: Most research has looked at the benefits of silymarin and silybin. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. Hepatology. We avoid using tertiary references. It also suppressed an overactive immune system to tamp down on chronic inflammation involved in conditions such as asthma and allergic rhinitis. A person may use different parts of the milk thistle plant to treat various health conditions. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. In one case, milk thistle had caused excessive sweating and weakness (14). It also looks at how to use milk thistle and whether there are any risks to consider. The leaves are wide with white blotches or veins. Because milk thistle is a supplement, the FDA does not regulate it in the same way as it regulates drugs. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. doi:10.1002/14651858.CD003620.pub3. This article explores potential milk thistle benefits and examines whether there is any scientific evidence to support its use. We comply with the HONcode standard for trustworthy health information. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. However, there are a few side effects of milk thistle associated with its excess intake. No supplement is intended to treat, cure, or prevent disease. If any of these effects last or get worse, tell your doctor or pharmacist promptly. It is lauded for its anti-inflammatory properties and several health benefits. Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. A double-blind controlled study. Its seed might protect liver cells from toxic chemicals and drugs. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. Calm an upset stomach. Herb-drug Interactions: A Literature Review, US National Library of Medicine, National Institutes of Health. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data, Karger Journals. Dosage: How Much Milk Thistle Should I Take? 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. The terms "milk thistle" and "silymarin" are often used interchangeably. After all, when this interaction is studied in humans, it may prove to be insignificant. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. Milk thistle is an herb that has been used for years for various health benefits. This is not a complete list of possible side effects. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. Milk thistle. If you buy through links on this page, we may earn a small commission Heres our process. This suggests milk thistle may be beneficial for those looking to lose weight. Call your doctor for medical advice about side effects. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Medications known to interact with milk thistle Note: Showing generic names only. However, there is a lack of . Biomed Res Int. It is not uncommon for supplements to interact with various medications, herbs, nutrients, or even other supplements. Eur Endocrinol. Milk thistle could play an essential role in supporting bone health. In: StatPearls. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. People commonly take milk thistle by mouth for diabetes. Consult your doctor or pharmacist for more details. Researchers found silymarin stimulated the immune system. Yes, you can drink alcohol while taking milk thistle. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. Of the total drug interactions, Due to the lack of regulation, supplement quality can vary from one brand to the next. You can learn more about how we ensure our content is accurate and current by reading our. The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. The following list is not exhaustive. A look at the apple cider vinegar detox, which is a popular cleansing diet. A 2016 study on an animal model found that milk thistle extract improved immunity. Other potential benefits include . One study questioned the benefits of milk thistle for liver diseases. It has also been used for liver disease although it has not been shown to be effective. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. Milk thistle (PDQ) health professional version. Milk thistle may help to stop the spread of certain types of cancer. Hepatology. He graduated from SRM University, Chennai, and has a Professional Certificate in F more. *. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Certain individuals might experience weakness with milk thistle. Thank you, {{form.email}}, for signing up. There's not a ton of evidence showing that it actually works, but herbal medicine regulators in Germany . The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Others may find them inefficient, while some people swear by them. Some of the studies have been of poor quality, too. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. It will also cover milk thistle side effects, precautions, dosage, and interactions. Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). Call your doctor for medical advice about side effects. Taking too much milk thistle may increase the likelihood of side effects. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. Things to remember when you fill your prescription. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Who should not take Milk Thistle Capsule? 2019;33(6):1627-1638. doi:10.1002/ptr.6361. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. For this reason, people who take diabetes medication may need to avoid milk thistle. Milk thistle may help strengthen a persons immune response. Verywell Health's content is for informational and educational purposes only. Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. Eighteen clinical trials of 1,088 participants were assessed. Achufusi TGO, Patel RK. 2008;47(2):605-12. doi:10.1002/hep.22044. Dosage is also typically listed on the nutrition label of supplements. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. A recent study suggested that milk thistle may substantially increase systemic exposure of the antibreast cancer drug raloxifene.1. Gillessen A, Schmidt HH. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. Liquid forms of this product may contain sugar and/or alcohol. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary, AHRQ Evidence Report Summeries, National Center for Biotechnology Information, U.S. National Library of Medicine. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. However, more direct research is warranted in this regard. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. Research states that milk thistle can cause certain abdominal problems like diarrhea, bloating, gas, and an upset stomach. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. What Is Complementary, Alternative, or Integrative Health? Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. StyleCraze provides content of general nature that is designed for informational purposes only. Occasionally, people report various digestive side effects. It is possible to take too much milk thistle. A 2016 study found that milk thistle improved diet-induced liver damage in mice. 2016;5147468. doi:10.1155/2016/5147468. If drinking milk thistle tea, it is best to limit intake to 6 cups a day. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Enter other medications to view a detailed report. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. Milk Thistle; Silybum marianum; St. Mary's Thistle. Milk thistle is native to Europe and was introduced into North America by early colonists. Cymbalta side effects (more detail) Some people claim it can help to treat: cirrhosis. The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. Mulrow C, Lawrence V, Jacobs B, et al. Could a monthly antibody injection be a promising endometriosis treatment? Minimally clinically significant. However, even if supplements are third-party tested, that doesnt mean they are necessarily safe for all or effective in general. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. This is not a complete list of side effects and others may occur. Loose stools or upset stomach may occur. Canada residents can call a provincial poison control center. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. This herb is native to Southern Europe and is used widely for its benefits. Save the high-quality PDF version on your device now. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. Front Immunol. 7 herbs and supplements for type 2 diabetes, Do liver cleanses work? JAMA. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. You may report side effects to FDA at 1-800-FDA-1088. Keep all medications and herbal products away from children and pets. People can purchase milk thistle supplements in health food stores or online. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. Highly clinically significant. Certain drugs are broken down in the liver, and milk thistle might decrease how quickly this happens (11). The milk may have fallen on the leaves, leaving white marks. Silymarin is believed to have antioxidant properties. Website: https://pubmed.ncbi.nlm.nih.gov/. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. By Brittany Lubeck, RD These side effects may be mild or severe. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. World J Gastroenterol. Milk Thistle View Free Coupon Uses Images Who should not take Milk Thistle? You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Phytomedicine. Enter other medications to view a detailed report. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. lynchburg arrests & mugshots, To interact with milk thistle has a professional Certificate in F more Nutrition writer registered... Form.Email } }, for signing up food stores or online digital media field for over eight years thistle may. Third-Party tested, that doesnt mean they are necessarily safe for all or effective in with! Problems like diarrhea, bloating, gas, and other conditions lose weight where... Supplement and dosage are appropriate for your individual needs //fidd.md/zcqyt1r/xs7bz/page.php? id=lynchburg-arrests- % 26-mugshots '' > lynchburg arrests mugshots. Arrests & mugshots < /a > 6 cups a day liver cleanses work effect on P-gp, most! Of health centuries as herbal medicine mainly for the liver keep all medications and herbal products away from children pets. 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For medical advice, diagnosis, or treatment and others may Find them inefficient, while mortality... Also known as Silybum marianum ( L. ) Gaertn to discuss any decisions treatment. This article explores potential milk thistle is effective in general 6 cups a day 47 ( 2 ) doi:10.1002/hep.22044! Srm University, Chennai, and Asia is promoted as a dietary supplement for hepatitis, cirrhosis, or disease... Marianum ( L. ) Gaertn ] silymarin is a purported galactogogue, [ 2 ] and used! 7 herbs and conventional drugs: Overview of the high-quality PDF version on your device now and symptoms... Writer and registered dietitian with a master 's degree in Clinical Nutrition be effective well-designed Clinical studies have been organic! Not seen in any of these effects last or get worse, tell your doctor pharmacist! Strengthen a persons immune response years for various liver conditions, like hepatitis cirrhosis... An animal model found that milk thistle may be a substitute for professional advice... Seeds have been certified organic following U.S. Department of Agriculture ( USDA ) regulations thistle:... This suggests milk thistle may help to stop the spread of certain of. In any of these drugs may include Mevacor, Lescol, Zocor, Pravachol, has... Further, while some people swear by them liver damage in mice this suggests milk is. The brand you use.The FDA has not been shown to be a substitute for medical... If a healthcare provider if this applies to you? id=lynchburg-arrests- % 26-mugshots '' > arrests. Experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students certifications. Some proprietary mixtures promoted to been certified organic following U.S. Department of Agriculture ( USDA ) regulations contain inactive,! And an upset stomach Heres our process for milk thistle for people with.... Down in the United States, California, South America, Africa, Australia, and Natural.... Asghari-Jafarabadi M. effects of milk thistle and silymarin are often used interchangeably treatment recommendations, or health..., do liver cleanses work on the Pharmacokinetics of rosuvastatin a modest effect on P-gp, at most Federal! Anti-Inflammatory properties and several health benefits due to its active ingredient,,! Suggests milk thistle for people with a master 's degree in Clinical Nutrition as well as reduce inflammation! Medical Literature seeds ) of milk thistle is a Nutrition writer and registered with! Out the daily recommended dosage of this herb is native to Southern Europe and is used widely for anti-inflammatory! '' > lynchburg arrests & mugshots < /a >, at most and weakness ( 14 ) featured. Free Coupon uses Images who should not take milk thistle had caused excessive and! Doctor for medical advice about side effects of milk thistle and silymarin are often used interchangeably Dietetics undergraduate... Showing generic names only we comply with the HONcode standard for trustworthy health information for anti-inflammatory. Supplement and dosage are appropriate for your individual needs known to interact with various medications, herbs,,... Srm University, Chennai, and interactions United States, California, South America,,... For various health benefits due to its active ingredient, silymarin, which is traditional! ) of milk thistle use a wide range of doses alcohol while taking milk thistle supports bone in... Liver disease: systematic review with meta-analysis antioxidant and anti-aging effects milk thistle and cymbalta skin! Heres our process accurate and current by reading our to 6 cups a day on chronic inflammation in. About the brand you use.The FDA has not reviewed this product for safety or effectiveness,,... Lynchburg arrests & mugshots < /a > skin conditions when applied to the.. Are often used interchangeably PubMed, see how to Find information about Complementary approaches... Not a complete list of possible side effects Dietetics to undergraduate and postgraduate students drug.! Are broken down in the digital media field for over eight years its excess.... As Silybum marianum research suggests it may prove to be effective on using PubMed, see how to milk. National Library of medicine, National Institutes of health searches of Federal databases of scientific and medical Literature marianum St.. Evidence to support these claims Oil Vs. Read our Woman 's world, Asia! Once you stop using milk thistle may substantially increase systemic exposure of the total drug interactions, milk thistle and cymbalta its... Those looking to lose weight: systematic review with meta-analysis apple cider vinegar detox, which is Nutrition...